Endocrine Abstracts

A new radiopharmaceutical using the somatostatin analogue octreotide has been developed for use in humans. SARTATE consists of the novel bifunctional chelator, MeCOSar, conjugated to (Tyr3)-octreotate. MeCOSar is a superior chelator for copper over a wide pH range and at room temperature, which allows for SARTATE to be used as an imaging/therapy pair when radiolabelled with copper-64 and copper-67.4Cu-SARTATE was produced by radiola...

We developed an improved process for producing high quality 67Cu using an electron accelerator instead of a high energy proton accelerator. The beta/gamma emitting radioisotope 67Cu was created using the (g,p) reaction on isotopically enriched 68Zn target (nominally 40 g, 98% enrichment). The high energy photons were produced by bremsstrahlung conversion of electrons from a 45 MeV electron LINAC. A specially designed water cooled converter, end...